Inhaling nitric oxide: a selective pulmonary vasodilator and bronchodilator.
نویسندگان
چکیده
CHEST / 105 / 3 / MARCH, 1994 / Supplement 87S Inhaling Nitric Oxide: A Selective Pulmonary Vasodilator and Bronchodilator* Warren M. Zapol, M.D., F.C.C.P.; Konrad J. Falke, M.D.; William E. Hurford, M.D., F.C.C.P.; and Jesse D. Roberts, Jr., M.D. I n a number of animal models and clinical pulmonary diseases of human subjects, inhaled nitric oxide (NO) is now firmly established as a selective pulmonary vasodilator.
منابع مشابه
Inhaled nitric oxide in congenital heart disease.
BACKGROUND Congenital heart lesions may be complicated by pulmonary arterial smooth muscle hyperplasia, hypertrophy, and hypertension. We assessed whether inhaling low levels of nitric oxide (NO), an endothelium-derived relaxing factor, would produce selective pulmonary vasodilation in pediatric patients with congenital heart disease and pulmonary hypertension. We also compared the pulmonary va...
متن کاملInhaled Nitric Oxide Counterbalances ET-1 Dependent Pulmonary Hypertension and Bronchoconstriction in the Pig
In anaesthetized, paralysed, ventilated pigs the ability of inhaled nitric oxide (80 ppm in 0(2)) to reduce the haemodynamic and respiratory effects of endothelin-1 administration (200 pmol/kg, i.v.) was evaluated. The mechanical properties of the respiratory system were evaluated by the rapid airway occlusion technique. The overall respiratory resistance, the interrupter resistance and the add...
متن کاملNitric oxide inhalation: effects on the ovine neonatal pulmonary and systemic circulations.
Others have shown that inhaled nitric oxide causes reversal of pulmonary hypertension in anaesthetized perinatal sheep. The present study examined haemodynamic responses to inhaled NO in the normal and constricted pulmonary circulation of unanaesthetized newborn lambs. Three experiments were conducted on each of 7 lambs. First, to determine a minimum concentration of NO which could reverse acut...
متن کاملPulmonary vasodilation by nitric oxide gas and prodrug aerosols in acute pulmonary hypertension.
Sodium 1-(N,N-diethylamino)diazen-1-ium-1,2-diolate (DEA/NO; Et2N-[N(O)NO]Na) is a compound that spontaneously generates nitric oxide (NO). Because of its short half-life (2.1 min), we hypothesized that inhaling DEA/NO aerosol would selectively dilate the pulmonary circulation without decreasing systemic arterial pressure. We compared the pulmonary selectivity of this new NO donor with two othe...
متن کاملBronchodilator action of inhaled nitric oxide in guinea pigs.
The effects of inhaling nitric oxide (NO) on airway mechanics were studied in anesthetized and mechanically ventilated guinea pigs. In animals without induced bronchoconstriction, breathing 300 ppm NO decreased baseline pulmonary resistance (RL) from 0.138 +/- 0.004 (mean +/- SE) to 0.125 +/- 0.002 cmH2O/ml.s (P less than 0.05). When an intravenous infusion of methacholine (3.5-12 micrograms/kg...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chest
دوره 105 3 Suppl شماره
صفحات -
تاریخ انتشار 1994